Perhaps a promotion gives an extra payout for a certain kind of bet, or you find a longshot future with a big edge.
There should be some specific reason for this plan, and your expected profit must be more than enough to cover the transactional costs of hedging. If a hedge or cashout offers far less than your bet’s present value, don’t do it.
If your team jumps out to a big lead and they’re 80% to cover, the current value is now $168: $210 *. An average point spread bet of $110 to win $100 has a present value of $105: $210 *. Hedging directly interferes with this goal since it involves paying the vig at least twice–once for each bet–so it should not be done on a whim.